Submitted by stacbrown14 on Wed, 18/02/2015 - 21:51.
Hello my name is Stacey my husband has been on dasatinib for cml for 14 months he is 34 and I am 27 we were trying to get pregnant when he was diagnosed, we are in the US and no one here thinks its a good idea to try. I was so happy when I found this site can anyone get me in touch with someone that could help thank you.
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Hi Stacey and welcome,
There has been a lot of discussion about the issue of male fertility and fathering children whilst on TKI therapy... see here for the full conversation thread from last year:
http://www.cmlsupport.org.uk/node/8477
Owing to the interest in this subject, I have asked my own doctor (expert CML with an interest in TKi and pregnancy) and she has advised that males taking TKIs are not at any greater risk of causing foetal abnormality than the normal population. (It is different for women as the risk to the foetus in the first trimester if taking TKI therapy is there.)
You might find the following link is from the EBMT Learning Programme for CML of some help....
Click the link for Module 3: Managing TKI treatments and special CML populations- which is a good (up to date) slide presentation regarding issues with CML and its therapy:
https://www.ebmt.org/Contents/Resources/Library/Resourcesfornurses/Docum...
This PPT presentation includes a section regarding pregnancy and fertility issues for both women and men, diagnosed with CML within child bearing age group (approx 10%) treated with TKIs. See start of the relevant section at:
slide 85: Fertility and Pregnancy
and
Slide 86
*CML gives rise to special issues during pregnancy since the condition requires lifelong therapy
*The situation differs for male and female patients'
For the current advice for Males fathering children when treated with TKIs scroll down to slides 99 - 101
Slide 101
Male - conclusions fertility and pregnancy studies:
*Due to possible adverse effects on male fertility sperm banking should be discussed at diagnosis as an option
*Studies show no suggestion of any problems in pregnancy, delivery or any increase in congenital abnormalities when the father is being treated for CML
*For male patients fathering children can be achieved without interruption of treatment
I hope this is of some help to you and you are able to convince your husbands doctor to at least consider doing some more research- or talking with other CML specialists. Let me know if you would like to get a second expert opinion on this and I will put you in contact with someone in the US who could advise you.
Best wishes,
Sandy
For all the EBMT modules on CML see this link:
https://www.ebmt.org/Contents/Resources/Library/Resourcesfornurses/Pages...