Nature News- Cellular 'alchemy' transforms skin into blood 7/11/2010
Published online 7 November 2010 | Nature | doi:10.1038/news.2010.588
Published online 7 November 2010 | Nature | doi:10.1038/news.2010.588
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Advances in the Treatment and Management of Patients With CML: A Nurse's Perspective CE Patricia S. Ault, MSN, RN
Editor's Note:
Chronic myeloid leukemia (CML) represents approximately 11% of all adult forms of leukemia, and in 2009, approximately 5050 cases were diagnosed in the United States.[1] Imatinib, which targets a constitutively active tyrosine kinase encoded by the chimeric BCR-ABL1 oncogene, was approved for use in 2001 and has been shown to induce durable responses and an overall survival rate of 89% at 5 years.[2]
Editor's Note:
Chronic myeloid leukemia (CML) represents approximately 11% of all adult forms of leukemia, and in 2009, approximately 5050 cases were diagnosed in the United States.[1] Imatinib, which targets a constitutively active tyrosine kinase encoded by the chimeric BCR-ABL1 oncogene, was approved for use in 2001 and has been shown to induce durable responses and an overall survival rate of 89% at 5 years.[2]
Second-Generation BCR-ABL Kinase Inhibitors in CML
CORRESPONDENCE Second-Generation BCR-ABL Kinase Inhibitors in CML; N Engl J Med 2010; 363:1672-1675October 21, 2010
CORRESPONDENCE Second-Generation BCR-ABL Kinase Inhibitors in CML; N Engl J Med 2010; 363:1672-1675October 21, 2010
CHMP positive recommendation for use of Tasigna in Newly Diagnosed Ph+ CML
Changing the Culture of Clinical Trials: Reviving a Failing Effort
Changing the Culture of Clinical Trials: Reviving a Failing Effort
2010 Sept 22, Lee Schwartzberg, MD, FACP, Editor-in-Chief
Cancer research is in big trouble. Surprised? Take issue with this statement? Yes, we know vastly more about what makes a cancer cell tick than we did a decade ago. A technical tour de force such as fully sequencing the cancer genome has been successfully performed, not just once but a dozen times. Not a day goes by without a report on personalized cancer care coming soon to a clinic near you. So what’s the problem?
Changing the Culture of Clinical Trials: Reviving a Failing Effort
2010 Sept 22, Lee Schwartzberg, MD, FACP, Editor-in-Chief
Cancer research is in big trouble. Surprised? Take issue with this statement? Yes, we know vastly more about what makes a cancer cell tick than we did a decade ago. A technical tour de force such as fully sequencing the cancer genome has been successfully performed, not just once but a dozen times. Not a day goes by without a report on personalized cancer care coming soon to a clinic near you. So what’s the problem?
NEJM article: “Liberating the NHS” — Another Attempt to Implement Market Forces in English Health Care
Nick Black, M.D.- N Engl J Med 2010; 363:1103-1105September 16, 2010
Nick Black, M.D.- N Engl J Med 2010; 363:1103-1105September 16, 2010
New BCR/Abl Inhibitor from Ariad Pharmaceuticals
Ponatinib (AP24534) Pivotal Trial in Drug-Resistant or Intolerant Chronic Myeloid Leukemia
Ariad's new drug for CML is now in clinical trial and has Orphan drug status from FDA and EMA. www.ariad.com
Ponatinib (AP24534) Pivotal Trial in Drug-Resistant or Intolerant Chronic Myeloid Leukemia
Ariad's new drug for CML is now in clinical trial and has Orphan drug status from FDA and EMA. www.ariad.com
Blood Journal-Long-term prognostic significance of early molecular response to imatinib
Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the international randomized study of interferon versus STI571 (IRIS). an analysis from the international randomized study of interferon versus STI571 (IRIS)
Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the international randomized study of interferon versus STI571 (IRIS). an analysis from the international randomized study of interferon versus STI571 (IRIS)
Haematology Times- EHA role of Patient Advocacy
Patient advocacy in clinical trials- EHA Congress, June 10-13th, 2010, Barcelona—Though recent developments aim to improve the clinical trial process, a group of experts says much more work is necessary.
Patient advocacy in clinical trials- EHA Congress, June 10-13th, 2010, Barcelona—Though recent developments aim to improve the clinical trial process, a group of experts says much more work is necessary.
Discovery suggests possible treatment strategy for aggressive leukemias
Researchers at Duke University Medical Center have identified a mechanism that could explain how patients move into the worst phase of chronic myelogenous leukemia (CML).
Researchers at Duke University Medical Center have identified a mechanism that could explain how patients move into the worst phase of chronic myelogenous leukemia (CML).