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Cytogenetic Response to Dasatinib Predictive for Progression-Free Survival in Imatinib-Resistant/Intolerant CML Patients

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Submitted by sandy craine on Fri, 19/12/2008 - 6:14pm
Capsule Summary CCO Independent Conference Coverage of the American Society of Hematology 2008 Annual Meeting* Cytogenetic Response to Dasatinib Predictive for Progression-Free Survival in Imatinib-Resistant/Intolerant CML Patients Posting Date: December 12, 2008 Analysis[1] of pooled data from 2 phase II clinical trials: SRC-ABL Tyrosine Kinase Inhibition Activity Research Trial (START)–C and START-R Summary of Key Conclusions Cytogenetic responses rapidly attained with dasatinib 70 mg twice daily in imatinib-resistant/intolerant patients with chronic-phase chronic myeloid leukemia (CML) 89% of all complete cytogenetic responses achieved within first 12 months of treatment 47% of responses achieved within first 3 months of treatment Cytogenetic responses highly durable with dasatinib therapy 91% of complete cytogenetic responses maintained during 24 months of follow-up Achieving both major cytogenetic response and complete cytogenetic response at 12 months highly predictive for PFS ....read more

Capsule Summary CCO Independent Conference Coverage of the American Society of Hematology 2008 Annual Meeting*

Cytogenetic Response to Dasatinib Predictive for Progression-Free Survival in Imatinib-Resistant/Intolerant CML Patients
Posting Date: December 12, 2008

Analysis[1] of pooled data from 2 phase II clinical trials: SRC-ABL Tyrosine Kinase Inhibition Activity Research Trial (START)–C and START-R
Summary of Key Conclusions
Cytogenetic responses rapidly attained with dasatinib 70 mg twice daily in imatinib-resistant/intolerant patients with chronic-phase chronic myeloid leukemia (CML)
89% of all complete cytogenetic responses achieved within first 12 months of treatment
47% of responses achieved within first 3 months of treatment
Cytogenetic responses highly durable with dasatinib therapy
91% of complete cytogenetic responses maintained during 24 months of follow-up
Achieving both major cytogenetic response and complete cytogenetic response at 12 months highly predictive for PFS

....read more

STIM Study Shows CML Complete Molecular Remission Possible to Maintain Following Imatinib Discontinuation

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Submitted by sandy craine on Fri, 19/12/2008 - 6:10pm
Summary Friday, December 19, 2008 Capsule SummaryCCO Independent Conference Coverage of the American Society of Hematology 2008 Annual Meeting* *CCO is an independent medical education company that provides state-of-the-art medical information to healthcare professionals through conference coverage and other educational programs.

Summary Friday, December 19, 2008
Capsule SummaryCCO Independent Conference Coverage of the American Society of Hematology 2008 Annual Meeting*

*CCO is an independent medical education company that provides state-of-the-art medical information to healthcare professionals through conference coverage and other educational programs.

SPIRIT: Higher MMR Rate With Imatinib/Peginterferon vs Imatinib Alone & Imatinib/Cytarabine in Patients with Newly Diagnosed CML

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Submitted by sandy craine on Fri, 19/12/2008 - 6:01pm
CCO Independent Conference Coverage of the American Society of Hematology 2008 Annual Meeting* *CCO is an independent medical education company that provides state-of-the-art medical information to healthcare professionals through conference coverage and other educational programs.

CCO Independent Conference Coverage of the American Society of Hematology 2008 Annual Meeting*

*CCO is an independent medical education company that provides state-of-the-art medical information to healthcare professionals through conference coverage and other educational programs.

Template letters to PCT and MP's for those who cannot access dasatinib or nilotinib

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Submitted by sandy craine on Fri, 19/12/2008 - 3:38pm
These letters are templates which you can use when writing to your PCT and MP when challenging negative funding decisions for alternatives to imatinib. f You should change the wording to suit your individual details and situation.

These letters are templates which you can use when writing to your PCT and MP when challenging negative funding decisions for alternatives to imatinib. f You should change the wording to suit your individual details and situation.

Scientists have discovered how cancer spreads

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Submitted by sandy craine on Fri, 19/12/2008 - 12:32pm
Scientists may be able to stop cancer spreading round the body Scientists have discovered how cancer spreads round the body raising the possibility it could be stopped.

Scientists may be able to stop cancer spreading round the body
Scientists have discovered how cancer spreads round the body raising the possibility it could be stopped.

New RCF report reveals striking postcode lottery

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Submitted by sandy craine on Fri, 19/12/2008 - 11:55am
New RCF report reveals striking postcode lottery in the chances of having an exceptional request for cancer treatment approved Monday, August 11, 2008 Rarer Cancers Forum carried out an audit of the policies and processes used by PCTs to determine exceptional funding requests. The audit found that:

New RCF report reveals striking postcode lottery in the chances of having an exceptional request for cancer treatment approved
Monday, August 11, 2008

Rarer Cancers Forum carried out an audit of the policies and processes used by PCTs to determine exceptional funding requests. The audit found that:

Patient's Right to Treatment: Applying for NHS Exceptional Funding for Treatment

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Submitted by sandy craine on Fri, 19/12/2008 - 11:38am
YOUR PATIENT'S RIGHT TO TREATMENT, written by Peter Telford Your Patient's Right to Treatment: Applying for NHS Exceptional Funding for Treatment This 32-page booklet was written by a barrister, Peter Telford. It was launched at

YOUR PATIENT'S RIGHT TO TREATMENT,
written by Peter Telford

Your Patient's Right to Treatment: Applying for NHS Exceptional Funding for Treatment
This 32-page booklet was written by a barrister, Peter Telford. It was launched at

IRIS data- 86 Percent of Patients With Ph+ CML alive after 7 years

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Submitted by sandy craine on Fri, 12/12/2008 - 12:44pm
Press Release Source: Novartis Pharmaceuticals UK Ltd Data Shows Longest Ever Survival for Patients With Life-Threatening Leukaemia Treated With Breakthrough Treatment Monday December 8, 5:00 pm ET - 86 Percent of Patients With Ph+ Chronic Myeloid Leukaemia Treated With Breakthrough Treatment Glivec(R) are Alive After Seven Years(1) - Treatment Shown to Slow Disease Progression: Only one Patient out of 317 Experienced Disease Progression Between Year Six and Seven of Treatment(1) - Data Demonstrate Longest Overall Survival Observed to Date in This Disease Area ....read full press release here

Press Release Source: Novartis Pharmaceuticals UK Ltd

Data Shows Longest Ever Survival for Patients With Life-Threatening Leukaemia Treated With Breakthrough Treatment
Monday December 8, 5:00 pm ET
- 86 Percent of Patients With Ph+ Chronic Myeloid Leukaemia
Treated With Breakthrough Treatment Glivec(R) are Alive After Seven Years(1)
- Treatment Shown to Slow Disease Progression: Only one Patient
out of 317 Experienced Disease Progression Between Year Six and Seven of
Treatment(1)
- Data Demonstrate Longest Overall Survival Observed to Date in
This Disease Area

....read full press release here

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