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DESTINY - Updates from those enrolled on the trial

Hi all, Just thought I would update how DESTINY was going for me. On Imatinib 200mg Diagnosed 2011, steady slowish fall over time to MMR ( just about hitting the goals back then which are actually quicker now, I mention to give a little positivity to those that are a little slower than others  ) and then onto a starting point of 0.012 IS Hammersmith at month 0.

Start - 0.012

Month 1 - 0.007 so lower !

Month 2 - 0.006

Month 3 - 0.036

Month 4 - 0.034

Month 5 - 0.042

Month 6 - 0.035​

Month 7 - 0.036

So nice and stable. Question for anyone on DESTINY that has stopped completely now, did you have similar numbers before stopping and see levels maintain afterwards around the same numbers, or rise - fail, or are we with detectable numbers still approaching the end of the 12 months 1/2 dose still. Seems from those I have seen here and on CML-UK Facebook that those coming off and doing well seems to have been undetectable at stopping point.

Month 8 to 10 - 0.04 basically for past 5 months,

Month 10 - 0.01 Great nice fall

Month 11 - 0.07 hummm

Month 12 - final PCR before stopping 0.12 Fail. so retest on Wednesday just gone, when this was the meeting to stop originally pencilled in. Result next week and then either a fail and full dose or stopping, quite a difference really on the basis of this result. So, here we go. Will post once hear.

 

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