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Glossary beginning with G
A generic drug is a pharmaceutical drug that is equivalent to a brand-name product in dosage, strength, route of administration, quality, performance, and intended use. For CML, as of 2017 generic imatinib is available in several countries. Generic versions of other TKIs are not, at this time, routinely available.
Carried in the DNA of every cell, genes hold all the information to build and maintain an organism and pass genetic traits to offspring. All organisms have genes corresponding to various biological traits, some of which are instantly visible (eye colour) some of which are not, (blood type). Derived from the Greek word genesis meaning “birth”, or genos meaning “origin”.
- Genetic code
The genetic code specifies the correspondence during protein translation between codons and amino acids. The genetic code is nearly the same for all known organisms.
At the molecular level, glitazones stimulate peroxisome proliferator-activated receptors (PPARs), specifically PPARγ, a ligand-activated nuclear transcription factor that modulates the expression of the gene-regulated proteins which control glucose and lipid metabolism.
Brand name in Australia, Europe and Latin America for imatinib mesylate, the first generation tyrosine kinase inhibitor used in the treatment of Ph+CML as well as some other cancers; known as Gleevec in Canada, South Africa and the USA.
- Graft versus Host Disease
A condition that occurs following bone marrow or stem cell transplant in which the donor's immune cells, in the transplanted marrow, make antibodies against the host's (patient recipient’s) tissues.
A control or ‘housekeeping gene’ used by some labs in qRT-PCR testing.