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New dug Miristen targets Leukemic stem cells

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https://www.businesswire.com/news/home/20180305005966/en/City-Hope-Study...

"City of Hope researchers aimed to find a treatment for CML that was effective enough for people to stop using TKIs. In their quest to find a cure for the disease, the team tested a drug called miristen. Developed at City of Hope, miristen targets one type of a microRNA that is expressed in leukemia stem cells, known as miR-126, and researchers believed to be important for self-renewal and persistence of stubborn leukemia stem cells"

Thank you Scuba for sharing this. Appreciate it. Lets have our fingers crossed.

This seems really impressing.

Looks like thay have not started testing it on human patients yet, alas.

Let's hope the good results are confirmed!

 

And here's another link to an article about miristen in the Hematology Times titled "Drug could improve treatment of CML":

https://www.hematologytimes.com/section/leukemias/article/drug-could-imp...

And here's a link to the nature.com article titled "Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia".

https://www.nature.com/articles/nm.4499

Works in mice - don't know if it will ever work in people. Will need a clinical trial - that takes years.

In the mean time - ask your Oncologist if he/she knows about Miristen and/or otherwise follows developments in CML.

If it works in mice maybe the mice will work in people.
Without the fur of course.

and a little salt.

Romo

New Drug May Be a Game Changer for Chronic Myeloid Leukemia Patients

Marcucci, Guido, MD

Oncology Times: June 20, 2018 - Volume 40 - Issue 12 - p 1,7–7
doi: 10.1097/01.COT.0000540282.91431.81
News

https://journals.lww.com/oncology-times/Fulltext/2018/06200/New_Drug_May...

 

If you download the PDF version, there's another article that seems to indicate that having some dirt in your life is a good thing when you're an infant.  Here's a sentence from that article: "Greaves suggests childhood ALL is a paradox of progress in modern societies — with lack of microbial exposure early in life resulting in immune system malfunction."

the article says: "the anxiety of living with a cancer that has a high chance of returning." I thought the likelihood of losing response to one of the second generation TKI's was fairly low.  This statement says just the opposite.  Why?

I think maybe what Guido is trying to get across is that CML is likely to return if the leukemic stem cells aren't fully eradicated by a TKI alone.  If miristen pans out as an effective agent then hopefully we'll all get a chance at TFR!

But the LSC's are not eradicated by any of the TKI's, at least that's what I understood, which is why their isn't a cure for CML.  Perhaps Scuba or Sandy can chime in here.  What is the long-term likelihood that CML will relapse and progress to AP/BP?  I've seen a few studies that suggest near normal life span for those who are initially and appropriately responsive to TKI's.  And I've also seen a study or 2 that say around 25% of all CML patients will relapse and advance to AP/BP. And now this statement that CML relapse is highly likely.  I know what we all hope, but what studies do we believe and why?

 

If miristen pans out as an effective agent then we'll be able to live less anxiously.  I think that's what he's trying to say.

I believe I read that when the LSCs are active they are reduced by TKIs, but the problem is that most of the time the LSCs are inactive.  It sounds like the research they've been doing has found that the TKIs actually encourage the LSCs to be inactive but that the miristen causes the LSCs to be more active and thus take in the TKI and then end their leukemic ways.

Here's the sentence from the article I'm talking about: "Inhibition of BCR–ABL by TKI treatment caused an undesired increase in endogenous miR-126 levels, which enhanced LSC quiescence and persistence."

This guy talks about the very thing you mention.
Short video.

https://www.youtube.com/watch?v=RvJ_xe5LEyY

Excessive tumor necrosis factor signaling.

Romo