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I cannot achieve MR4.0

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Hello. I am diagnosed as CML at October 2015. Since then I have used Sprycel.
and below is my IS% score.

Oct 2015: 80% when diagnosed.
Dec 2015: 1%
Feb 2016: 0.06%
Mar 2016: 0.03%
... fixed at 0.03%
Mar 2017: 0.014%
... fixed at 0.014%
Jun 2018: 0.014%

So, my results have long been fixed at 0.014%. My doctor says it is not a problem, but the score
will be the same, and should change TKI if I want stop it in future.

Does anyone have the same sequence as me, and
improved after that? I am not sure if I should change to Bosulif.

Most stop trials require 3 years of treatment and 1 year of sustained MR 4.5 (.0032%), so you are close on both counts.  Many of us have plateaus like yours and then go lower.  What dose are you currently on?  If 100 mg, you are already a candidate for dose reduction and should press your doctor for that first.  There are some studies emerging that suggest a lower dose of Sprycel is actually more effective.

I wouldn't change unless you have serious side effects.  Go for dose reduction first - many do fine or even better at 20 mg Sprycel per day. Good luck

Totally agree with this. 0.014% is a deep response and a very good place to be. There is absolutely no reason to do anything other than keep going on as before. We should not get obsessed with lower and lower numbers really when already in a great place.

David.

Yes, I stayed where you are for about two years and then started getting "<0.01" for a year and now 0.005 and 0.006.  The latter two on 20 mg Sprycel.

Here is my history in case it's helpful. I started on 100mg Sprycel and went to 50mg after the first six months. 

Kat, I LOVE the fact that your BCR ABL level has decreased on 20mg. Very inspiring indeed!

BCR-ABL (IS)
46.77  April 2016
3.568  July 2016 
0.076  Oct 2016
0.016  Feb 2017
0.0079  April 2017
0.014  July 2017
0.019  Sept 2017
0.011  Nov 2017
0.019  Jan 2018
0.0093 Apr 2018

Thank you for your history, Isla. Now I feel safer that others have pleteaus for long time like me.
Also thank you for the infomation of dose reduction. I think I am on the right truck, and would not change TKI.