Sprycel and weight gain

Hi Skeltonn I put 2 stone in the first 12 months and to be honest 4 years later haven’t really chipped much of that off! but it hasn’t gone up any more, just seemed to have levelled off, fatigue, never thankfully had a problem, but these fantastic drugs that keep us ticking over effect people differently.

Yes and yes. I had terrible fatigue on 140mg. I also waxed and waned between diarrhea and constipation, which amplified the fatigue. And I was only on at that dose for 3.5 weeks. I did also gain some weight despite not having much appetite. Weight gain is likely connected to fluid retention, a common side effect of Sprycel. When I started the nurses said weigh yourself every morning. Contact us if you gain more than a pound in one day, or 4 pounds in a week. I never contacted them as I was kind always hovering on that threshold. But I know I had fluid on my lungs and heart, I could feel it. Probably the thing that would help most is if you could reduce your dose without sacrificing effectiveness. I’m currently taking 50mg every other day and don’t have as many side effects that are felt physically, just the  myelosuppression, which is very serious but doesn’t ‘feel’ too bad in and of itself.