Im sorry about my delayed response... I dont always log on and check this website.
I am happy to say that my husband and I gave birth to a PERFECTLY healthy baby girl 8 weeks ago on the 20th August. The dasatanib has not affected her at all!
Ill give you some background information about where we were at. My husband was 32 when diagnosed 4.5 years ago. He spent 2.5 years on Glivec, and then switched to dasatanib due to a P-Loop mutation. He had been taking dasatanib for 2 years. I was 28 when I fell pregnant, and gave birth 3 days after my 29th birthday!
I spent alot of time researching dasatanib and pregnancy, and every case that I found where the male was taking the dasatanib, the baby was perfectly healthy.
My husbands haematologist contacted the drug supplier of sprycel in Australia, and we received information on other pregnancies that they have tracked.
I'll type it in below for you...and for others... as it was quite reassuring to us.
From Bristol-Myers Squib...
"The potential effects of dasatinib on sperm have not been studied. Sexually active male patients taking dasatinib should use adequate contraception. No specific studies have been conducted in animals to evaluate the effects of dasatinib on fertility. Dasatinib caused atrophy/degeneration of the testis in rats and monkeys and an increase in the number of copora lutea in the ovaries in rates at doses producing plasma exposure levels below or close to that anticipated in patients receiving dasatinib therapy.
A poster presentation at the American Society of Hematology, 2008 assessed the effects of dasatinib in 13 female patients who became pregnant, and 9 male patients who conceived children while receiving therapy with dasatinib. The assessment was presented as patient case studies from dasatinib trials and postmarketing reports.
Data was obtained via clinical study reports for 16 patients in phase I-III dasatinib trials and post-marketing surveillance compiled from 6 voluntarily submitted reports from community physicians. Due to the limited data, and the absence of any robust data, the outcomes of this analysis should be interpreted with caution.
The baseline characteristics of the 9 male patients are described in the table below.
(I cant insert the table, so will just put it in as best I can.)
Table. Baseline characteristics of male patients who conceived children whilst on dasatinib therapy.
Patient A - Age (not reported), Disease (not reported), months on dasatinib (not reported), risk factors (not reported)
Patient B - Age (38), Disease (Chronic Phase - Chronic Myeloid Leukaemia), Months on Dasatinib (12), Risk factors (previous cytarabine therapy; partner on oral contraceptive ethinylestradiol)
Patient C - Age (34), Disease (Chronic Phase - Chronic Myeloid leukaemia), Months on Dasatinib (6), Risk factors (previous therapy with hydroxyurea, anagrelide; multiple concomitant medications including influenza vaccine)
Patient D - Age (43), Disease (Blast crisis - chronic myeloid leukaemia), Months on dasatinib (10), Risk factors - (Anemia; bleeding tendency; prior hydroxyurea therapy; concomitant antibiotics)
Patient E - Age (32), Disease - (chronic myeloid leukaemia), Months on dasatinib (not reported), risk factors - (history of GVHD; ex-tabacco use; prior hydroxyurea, interferon and cytarabine therapy)
Patient F - Age (41), Disease - (chronic myeloid leukaemia), months on dasatinib (7), risk factors (psoriasis; sleep apnea; prior interferon therapy; multiple concomitant medications)
Patient G - Age (49), Disease - (Chronic Phase - chronic myeloid leukaemia), Months on dasatinib (8), risk factors (age; alcohol and tabacco use; concomitant furosemide and lorazepam)
Patient H - Age (not reported), disease (not reported) months on dasatinib (1) risk factors (not reported)
Patient I - Age (24), disease (chronic myeloid leukaemia), months on dasatinib (1), risk factors (not reported)
The outcomes of infants born are available for seven of the nine patients. In all cases, normal, healthy infants were born to partners.
Please note that Bristol-Myers Squibb does not recommend the use of Sprycel in any manner that is inconsistent with that described in the full prescribing information. For a complete discussion of Sprycel please refer to the full prescribing information. "
I hope this information is of some help to you. I am hoping that our pregnancy can help others who are wanting to conceive...