Congratulations. For women who have a diagnosis of CML and who are treated with TKI therapy it is not recommended that they continue with this drug therapy if they plan to get pregnant or if they accidentally find they have become pregnant. From what I have read, TKIs can be the cause of abnormalities if the foetus is exposed in the first trimester (3 months) of development. However there is different advice for males. There seems to be no correlation between TKI use and any effect on sperm - other than on sperm count so treatment may affect fertility... so it is considered safe for men to father a child whilst on therapy with TKIs.
I suggest you talk with your doctor about this issue if it would reassure your wife. To my knowledge there have been many children born to men who are being treated with TKI therapy without a rise in the rate of abnormalities above rates found in the normal (non CML) population. You most certainly will not pass on CML to your child for the reasons Darley has outlined.
Wishing you and your wife a peaceful and safe pregnancy,
Sandy