I started 100mg/day Sprycel last Friday and my Doc said he didn't want any blood work done until 6 weeks of Sprycel. I never had a problem with my counts on Gleevec, but it seems like the prescribing information (see below) is saying a CBC should be done at two weeks. Am I missing something, or should I have a CBC before 6 weeks? For those of you who switched to Sprycel, how often did you get a CBC when you started on it?
You've got a great site here! Thanks for hosting it!
Here's my history:
09/2012 p210 transcript 118.7% IS @ Dx, begin Gleevec 400mg/day
12/2012 003.59% & bone marrow biopsy - no residual myeloproliferative features but detected 1/20 metaphases containing the Philadelphia chromosome
2013 000.914%, 000.434%, 000.412% 10/2013 000.360% & bone marrow biopsy - normal male karyotype with no evidence of a clonal cytogenetic abnormality
2014 000.174%, 000.088%, 000.064%
2015 000.049%, decrease to Gleevec 200mg/day, 000.035%, 000.061%, 000.028%
2016 000.041%, 000.039%, 000.025%
2017 000.029%, 000.039%, switched to generic imatinib 200mg/day, 000.070%, 000.088%
2018 000.233%, switched to dasatinib 100mg/day - I want zero #4 back!
5 WARNINGS AND PRECAUTIONS 5.1 Myelosuppression Treatment with SPRYCEL is associated with severe (NCI CTCAE Grade 3 or 4) thrombocytopenia, neutropenia, and anemia, which occur earlier and more frequently in patients with advanced phase CML or Ph+ ALL than in patients with chronic phase CML.
In patients with chronic phase CML, perform complete blood counts (CBCs) every 2 weeks for 12 weeks, then every 3 months thereafter, or as clinically indicated.
In patients with advanced phase CML or Ph+ ALL, perform CBCs weekly for the first 2 months and then monthly thereafter, or as clinically indicated. Myelosuppression is generally reversible and usually managed by withholding SPRYCEL temporarily and/or dose reduction [see Dosage and Administration (2.5) and Adverse Reactions (6.1)].